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Langerhans Cell Histiocytosis

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This was a one-year-old who presented with

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pain along the right lateral orbit.

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The serial imaging here shows a lesion which is

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involving the lateral orbital wall and superior orbital

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wall. It is a bony lesion in a one-year-old.

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Our differential diagnosis for bone lesions in the

0:25

infant and young toddler age includes Langerhans

0:31

cell histiocytosis. Alternatively,

0:35

one might suggest a possible diagnosis of neuroblastoma

0:39

with a primary tumor in the abdomen and secondary

0:42

involvement of the bones of the face and/or

0:45

the skull all comers throughout the world.

0:48

One also might consider involvement of tuberculosis

0:52

affecting the skull and the facial bones.

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In this case,

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the patient shows heterogeneous signal intensity on the

1:02

FLAIR imaging as well as T2-weighted scans

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as well as the post-contrast scans.

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We also note that there appears to be some extraosseous

1:13

involvement with soft tissue enhancement that is

1:16

occurring along the temporalis muscle at the edge of the skull.

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What would be helpful is to have the CT scan in this

1:25

case to identify whether or not this was a punched-out

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lesion that one would expect with Langerhans cell

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histiocytosis. Indeed, that was the case.

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However, we get the sense of that on the axial post-contrast imaging

1:40

and scan where we are losing the edge of the lesion at the bony margin.

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In this age group,

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the best diagnosis is Langerhans cell histiocytosis.

Report

Description

Faculty

David M Yousem, MD, MBA

Professor of Radiology, Vice Chairman and Associate Dean

Johns Hopkins University

Tags

Pediatrics

Orbit

Neuroradiology

Neuro

Neoplastic

Musculoskeletal (MSK)

MRI

Head and Neck

Bone & Soft Tissues

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