0:01

Here is an example of an IDH mutated glioma

0:05

in a patient, 28-year-old male,

0:08

presenting with headaches and otherwise clinically intact.

0:12

You can see that MRI shows a very large

0:17

tumor involving the frontal lobe.

0:19

It's actually extending across the midline by the volatile

0:23

frontal lobe involvement,

0:25

with hardly any edema

0:27

around this very well-defined mass,

0:30

which shows some heterogenous fatty enhancement

0:33

within the tumor, and more importantly,

0:36

if you look at the CT scan done a day earlier,

0:40

it actually shows you that this tumor

0:42

has some areas of calcification,

0:45

which in fact could also be confirmed on

0:49

the susceptibility weighted imaging.

0:52

All our brain tumor patients

0:54

also undergo susceptibility weighted imaging sequences,

0:57

and you can see these tumors

1:00

are mutated gliomas.

1:03

They might show areas of hemorrhage

1:06

as this one is showing,

1:07

but also some of these susceptibility blooming signal,

1:12

which we are seeing,

1:13

is also related to calcification.

1:16

As you can see, some of these areas are dark on

1:19

phase imaging right over here,

1:21

which kind of corresponds to the calcification

1:24

we saw on the CT scan.

1:27

So, you know, these tumors,

1:29

they could be calcified,

1:30

and once we see the calcification in a tumor,

1:34

which looks like that, in the frontal lobe in a young patient,

1:38

you can suggest a diagnosis of an oligodendroglioma,

1:41

which this turned out.

Case: IDH-Mutant Oligodendroglioma, Grade 2

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0:01

Here is an example of an IDH mutated glioma

0:05

in a patient, 28-year-old male,

0:08

presenting with headaches and otherwise clinically intact.

0:12

You can see that MRI shows a very large

0:17

tumor involving the frontal lobe.

0:19

It's actually extending across the midline by the volatile

0:23

frontal lobe involvement,

0:25

with hardly any edema

0:27

around this very well-defined mass,

0:30

which shows some heterogenous fatty enhancement

0:33

within the tumor, and more importantly,

0:36

if you look at the CT scan done a day earlier,

0:40

it actually shows you that this tumor

0:42

has some areas of calcification,

0:45

which in fact could also be confirmed on

0:49

the susceptibility weighted imaging.

0:52

All our brain tumor patients

0:54

also undergo susceptibility weighted imaging sequences,

0:57

and you can see these tumors

1:00

are mutated gliomas.

1:03

They might show areas of hemorrhage

1:06

as this one is showing,

1:07

but also some of these susceptibility blooming signal,

1:12

which we are seeing,

1:13

is also related to calcification.

1:16

As you can see, some of these areas are dark on

1:19

phase imaging right over here,

1:21

which kind of corresponds to the calcification

1:24

we saw on the CT scan.

1:27

So, you know, these tumors,

1:29

they could be calcified,

1:30

and once we see the calcification in a tumor,

1:34

which looks like that, in the frontal lobe in a young patient,

1:38

you can suggest a diagnosis of an oligodendroglioma,

1:41

which this turned out.

Report

Faculty

Rajan Jain, MD

Professor of Radiology and Neurosurgery

New York University Grossman School of Medicine

Lesson

Introduction

Lesson

Meningiomas

Lesson

Non-glial Tumors

Lesson

2021 WHO CNS Tumor Classification

Lesson

Gliomas

Case: IDH-Mutant Oligodendroglioma, Grade 2