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Case: Defining Meningioma

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Dr. Laser,

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a lot of your young colleagues often ask,

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"Well, what's a meningioma? What really is it?"

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Well, it's a tumor.

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It arises from arachnoid capsules in the extra-axial space.

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So, it's an extra-axial monoclonal tumor.

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There's a meningioma gene, by the way,

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so this is a good bar question where

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you can win a free beer.

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And that meningioma gene is found on chromosome 22.

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It's no secret that in neurofibromatosis type 2 or NF2,

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chromosome 22 also has a mutation.

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So the meningioma, the isolated meningioma,

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has an abnormality on chromosome 22 that is located

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between myoglobin and the c-sis proto-oncogene.

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And patients with NF2 have a different abnormality,

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but also on chromosome 22.

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Everybody knows,

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or if you don't, you know it now,

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that individuals with NF2 get multiple meningiomas.

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And by the way,

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speaking of multiple meningiomas,

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there's also a phacomatosis called

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multiple meningiomatosis,

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which is frequently unilateral, but can be bilateral.

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Meningioma, an extra-axial mass

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arising from arachnoid cap cells,

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demonstrated here in the olfactory groove on T1 C-,

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T1 C+ and T2 spin echo MR imaging

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in an extra-axial location.

Report

Faculty

Stephen J Pomeranz, MD

Chief Medical Officer, ProScan Imaging. Founder, MRI Online

ProScan Imaging

Tags

Oncologic Imaging

Neuroradiology

Neoplastic

MRI

Brain

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