0:02

in a 14-year-old with seizures,

0:06

with known tuberous sclerosis complex.

0:09

We can see on T2-weighted imaging,

0:11

we can see several subependymal nodules.

0:13

Along the lateral margin of the body

0:15

of both lateral ventricles.

0:18

And if we look at susceptibility-weighted imaging,

0:22

we can see these are hypointense

0:25

on susceptibility-weighted imaging,

0:27

representing mineralization.

0:30

A CT scan can confirm these

0:34

areas of calcification.

0:36

Now, notice in the right frontal lobe,

0:41

in the anterior aspect of the

0:42

right middle frontal gyrus,

0:43

there's a juxtaportical curvilinear area of

0:46

mineralization at the depth of this sulcus.

0:49

That represents,

0:51

we can see this here on T2-weighted imaging,

0:55

we can see this bottom of the

0:57

sulcus dysplasia with.

1:00

This hypointense area representing the

1:02

mineralization and this area of

1:04

signal abnormality around it.

1:07

So this is a patient with tuberous sclerosis

1:10

complex with a mineralized area of dysplasia.

1:14

Now, additionally, though,

1:17

if you look at the CT scan, look posteriorly,

1:20

you can see there's skin thickening and

1:25

in addition to the skin thickening,

1:27

we can see on MR.

1:29

There is bony sclerosis.

1:33

Skin thickening is a known dermatologic

1:35

manifestation of tuberous sclerosis complex.

1:40

Areas of bony sclerosis,

1:42

which can look more amorphous

1:46

and large like these,

1:47

or can look simply more like

1:49

boneless or anastomosis,

1:51

are very common in tuberous sclerosis complex.

1:54

They can be mistaken for other entities.

1:56

If you're not familiar that tuberous

1:59

sclerosis complex can.

2:00

And have these bony sclerotic areas.

2:04

So this patient has tuberous sclerosis complex

2:08

with calcified subependymal nodules,

2:10

a mineralized area of dysplasia in the right

2:13

frontal lobe and also right parietal occipital

2:18

scalp thickening and multiple

2:20

areas of bony sclerosis.