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This is an MRI scan in an eleven-year-old

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with developmental delay and seizures.

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As we scroll through,

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we encounter a number of abnormalities.

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First, on this sagittal T1 weighted image,

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we see a thickened splenium and isthmus

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of the corpus callosum.

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And we don't see the anterior portions

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of the corpus callosum.

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We don't see that most of the body,

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the genu or the rostrum of the corpus callosum.

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We see a somewhat thickened anterior commissure.

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As we scroll up,

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we see a closed lip schizencephalic cleft

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going to the lateral margin of the

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posterior body of the right lateral ventricle,

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lined by Polymicrogyria.

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You can see here,

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there are areas of polymicrogyria

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adjacent to this closed lip schizencephalic cleft.

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Here, adjacent to the frontal

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horns of the lateral ventricles,

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we're seeing extra areas of gray matter.

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This is called gray matter heterotopia.

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In the left cerebral hemisphere,

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almost corresponding to the same location

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as this closed lip schizencephalic cleft,

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we're seeing something that looks very similar.

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We're seeing a deep sulcus,

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but the sulcus doesn't go all the way to

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the margin of the lateral ventricle.

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We do see a little trail of

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gray matter heterotopia.

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So, this is actually what's called a transmantle

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gray matter heterotopia in the

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setting of a deep sulcus.

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So this patient has a transmantle heterotopia

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with a deep sulcus and some areas of

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polymicrogyria adjacent to it.

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On the right side,

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we have a closed-lip schizencephaly,

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lined by polymicrogyria.

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We have several additional areas of gray matter

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heterotopia and we have dysgenesis of the anterior

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and mid portions of the corpus callosum.