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Inflammatory Breast Cancer Overview

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So our next topic is inflammatory breast cancer

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which can sometimes be difficult to

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distinguish from, um, mastitis or some

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of these more chronic forms of mastitis.

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So in inflammatory breast cancer,

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there are rapid changes in the skin overlying

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the affected breast with erythema, edema,

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or "peau d'orange," orange peel kind of skin.

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And that develops usually over

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the course of about 3 to 6 months.

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The skin changes usually affect

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at least a third of the breast.

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There should be pathologic evidence of

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invasive breast cancer in order to prevent it,

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called inflammatory breast cancer.

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And this represents 2% to 4%

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of all breast cancers.

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And the histopathology shows scattered

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tumor emboli and dermal lymphatic invasion.

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There's a higher rate of HER2

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and triple-negative subtypes.

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Those skin changes can be mistaken for

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mastitis, so this can be a delayed diagnosis.

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And diagnostic clues include a little

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bit older age, age over 50,

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diffuse erythema, and no systemic symptoms.

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So these patients often have all these

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changes, but it's relatively painless

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without the symptoms of fever and chills.

Report

Faculty

Lisa Ann Mullen, MD

Assistant Professor; Breast Imaging Fellowship Director

Johns Hopkins Medicine

Tags

Women's Health

Ultrasound

Tomosynthesis

Neoplastic

Mammography

Breast

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